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5-HT4 antagonist 1

CAS No. 261766-73-8

5-HT4 antagonist 1( —— )

Catalog No. M26034 CAS No. 261766-73-8

5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).

5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    5-HT4 antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).
  • Description
    5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6). (In Vivo):5-HT4 antagonist 1 demonstrates good exposure and prolongs t1/2 in other species with t1/2 of 7, 12, and 21 hours for mice, rats, and mini-pig.
  • In Vitro
    5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.
  • In Vivo
    5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    Non-cleavable
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    261766-73-8
  • Formula Weight
    480.62
  • Molecular Formula
    C23H36N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (41.61 mM)
  • SMILES
    CN1CCN(CC1)S(=O)(=O)CCCN1CCC(CNC(=O)c2cccc3OCCOc23)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.
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