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5-HT4 antagonist 1
CAS No. 261766-73-8
5-HT4 antagonist 1( —— )
Catalog No. M26034 CAS No. 261766-73-8
5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 222 | Get Quote |
|
| 10MG | 335 | Get Quote |
|
| 25MG | 566 | Get Quote |
|
| 50MG | 806 | Get Quote |
|
| 100MG | 1098 | Get Quote |
|
| 500MG | 2205 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name5-HT4 antagonist 1
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NoteResearch use only, not for human use.
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Brief Description5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6).
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Description5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6). (In Vivo):5-HT4 antagonist 1 demonstrates good exposure and prolongs t1/2 in other species with t1/2 of 7, 12, and 21 hours for mice, rats, and mini-pig.
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In Vitro5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.
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In Vivo5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorNon-cleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number261766-73-8
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Formula Weight480.62
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Molecular FormulaC23H36N4O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (41.61 mM)
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SMILESCN1CCN(CC1)S(=O)(=O)CCCN1CCC(CNC(=O)c2cccc3OCCOc23)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dale Boger.et al. Chimer containing a targeting portion linked to a scission-activated duocarmycin-type prodrug. WO2009064913A1.
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